Recent publications:

F. Mazza, E. Tronconi, A. Valerio, M. Groettrup, M. Kremer, A. Tossi, F. Benedetti, A. Cargnel, C. Attori (2006) The Non-Peptidic HIV Protease Inhibitor Tipranavir and Two Synthetic Peptidomimetics (TS98 and TS102) Modulate Pneumocystis carinii Growth and Proteasome Activity of HEL299 Cell Line. J Eukaryot Microbiol. 53(Suppl 1):S144-6

M. Benincasa, M. Scocchi, S. Pacor, A. Tossi, D. Nobili, G. Basaglia, M. Busetti, R. Gennaro (2006) Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts. J Antimicrob Chemother. 58(5):950-9.

I. Zelezetsky, A. Pontillo, L. Puzzi, N. Antcheva, L. Segat, S. Pacor, S. Crovella, and A. Tossi, Evolution of the primate cathelicidin - correlation between structural variations and antimicrobial activity J. Biol. Chem. 281(29):19861-71.

N. Antcheva, I. Zelezetsky and A. Tossi (2006) “Cationic Antimicrobial Peptides—The Defensins” in The Handbook of Biologically Active Peptides, A.J. Kastin Ed. Chapter 11, pp. 55-66, Elsevier, Burlington, MA.

I. Zelezetsky, A. Tossi (2006) Alpha-helical antimicrobial peptides-Using a sequence template to guide structure-activity relationship studies. Biochim Biophys Acta. Apr 18; [Epub ahead of print]

M. Boniotto, W. J. Jordan, J. Eskdale, A. Tossi, N. Antcheva, S. Crovella, N. D. Connell , G. Gallagher. (2006) Human beta-defensin 2 induces a vigorous cytokine response in peripheral blood mononuclear cells. Antimicrob. Agents Chemother. . Antimic. Agents Chemother. (in press)

I. Zelezetsky, U. Pag, H-G. Sahl A. Tossi (2005) Tuning the biological properties of amphipathic alpha-helical antimicrobial peptides: Rational use of minimal amino acid substitutions. Peptides. . Peptides 26(12): 2368-2376

M. Scocchi, I. Zelezetsky, M. Benincasa, R. Gennaro, A. Mazzoli, A. Tossi (2005) Structural aspects and biological properties of the cathelicidin PMAP-36. FEBS J. 272:4398-4406

I. Zelezetsky, S. Pacor, U. Pag, N. Papo, Y. Shai, H.-G. Sahl, A. Tossi (2005) Controlled alteration of the shape and conformationalstability of alpha-helical cell-lytic peptides: effect on mode of action and cell specificity. Biochem. J. 390:(Pt.1) 177-188

S. Crovella, N. Antcheva, I. Zelezetsky, M. Boniotto, S. Pacor, M. V. Verga Falzacappa, and A. Tossi (2005) Primate beta-defensins – structure, function and evolution. Current Prot. Pept. Sci. 6:7-21.

I. Zelezetsky, U. Pag, N. Antcheva, H.-G. Sahl, and A.Tossi (2005) Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. Arch. Biochem. Biophys. 434:358-364

H.-G. Sahl, U. Pag, S. Bonness, S. Wagner, N. Antcheva and A. Tossi (2004) Mammalian Defensins: Structures and Mechanism of Antibiotic Activity J Leukoc Biol.

T. Schneider, M. Senn, B. Berger-Bächi, A. Tossi, H-G. Sahl and I. Wiedemann, (2004). In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus Mol. Microbiol. 53(2):675-85.

M. Ventura, M. Boniotto, M. Pazienza, V. Palumbo, M.F. Cardone, M. Rocchi, A. Tossi, A. Amoroso, S. Crovella (2004) Localization of beta-defensin genes in non human primates. Eu.r J. Histochem. 48(2):185-90

N. Antcheva, M. Boniotto, I. Zelezetsky, S. Pacor, M. V. Verga Falzacappa, S. Crovella and A. Tossi (2004) The effect on antimicrobial activity of positively selected sequence variation in human and Macaca fascicularis beta-defensin 2. Antimicrob. Agents Chemother.48:685-688

F. Benedetti, F. Berti, S. Miertus, D. Romeo F. Schillani, A. Tossi (2003) Design, synthesis and preliminary evaluation of peptidomimetic inhibitors of HIV aspartic protease with an epoxyalcohol core. ARKIVOC (xiv) 140-154.

A. Tossi, F. Benedetti, S. Norbedo, D. Skrbec, F. Berti, (2003) Small Hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases, Bioorg. and Med.Chem. 11:4719-4727.

M. Boniotto, N. Antcheva, I. Zelezetsky, A. Tossi, V. Palumbo, M. V. Verga Falzacappa, S. Sgubin, L. Braida, A. Amoroso, S. Crovella (2003) A study of host defence peptide beta-defensin 3 in primates. Biochem. J. 374:707-714.

M. Boniotto, A. Tossi, M. DelPero, S. Sgubin, N. Antcheva, D. Santon, J. Masters, S. Crovella(2003) Evolution of the beta-defensin 2 gene in higher primates. Genes and Immunity, 4:251-257.

A. Tossi, L. Sandri, A. Giangaspero (2002) New consensus hydrophobicity scale extended to non-proteinogenic amino acids. In Peptides 2002: Proceedings of the twenty-seventh European peptide symposium. Edizioni Ziino, Napoli, Italy. pp. 416-417.

A. Tossi, N. Antcheva, I. Zelezetsky, S. Pacor, U. Pag, H.-G. Sahl (2002) Synthetic antimicrobial peptides designed from sequence templates. In Peptides 2002: Proceedings of the twenty-seventh European peptide symposium. Edizioni Ziino, Napoli, Italy. pp. 302-303.

A. Nair, I. Bonin, A. Tossi, W. Welsh and S. Miertus (2002) Computational studies of the resistance patterns of mutant HIV-1 aspartic proteases towards ABT-538 (ritonavir) and design of new derivatives, J. Molec. Graphics Modelling 21:171-179.

D. Pantarotto, A. Bianco, F. Pellarini, A. Tossi, A. Giangaspero, I. Zelezetsky, JP. Briand, M. Prato (2002) Solid-Phase Synthesis of Fullerene-peptides. J. Am. Chem. Soc. 124:12543-12549

S. Pacor, A. Giangaspero, M. Bacac, G. Sava and A. Tossi. (2002) Analysis of the cytotoxicity of synthetic antimicrobial peptides on mouse leukocytes: Implications for systemic use. J. Antimic. Chemother. 50:339-48.

M. Boniotto, A. Tossi and S. Crovella (2002) Differentiation of beta-defensin 2 in rhesus monkey (Macaca mulatta) and long-tailed macaque (M. fascicularis), Clin. Diagnos. Lab. Immunol. 9: 503-504.

A. Tossi, L. Sandri (2002) Molecular diversity of ribosomially synthesized cationic antimicrobial polypeptides.(Review) Curr. Pharm. Design, 8: 743-761

A. Giangaspero, L. Sandri, A. Tossi (2001) Amphipathic, alpha-helical antimicrobial peptides: a systematic study of the effects of structural and physical properties on biological activity. European Journal Biochemistry 268: 5589-5600.

F. Pellarini, D. Pantarotto, T. Da Ros, A. Giangaspero, A. Tossi and M. Prato (2001) A Novel [60]Fullerene Amino Acid for Use in Solid-Phase Peptide Synthesis Org. Lett. 3(12):1845-1848.

A. Tossi, L. Sandri and A. Giangaspero (2000) Amphipathic, alpha-helical antimicrobial peptides. Biopolymers 55 (1): 1-30.

A. Tossi, I. Bonin, N. Antcheva, S. Norbedo, F. Benedetti, S. Miertus, A. C. Nair, T. Maliar, F. dal Bello, G. Palù and D. Romeo (2000) Aspartic protease inhibitors: an integrated approach for the design and synthesis of diaminodiol based peptidomimetics, Eur. J. Biochem. 267: 1715-1722.