(N.B. annotations are similar to those used in SWISS-PROT
ID DGCN_DRAMY SUBMITTED; PRT; 47 AA. AC P 22222; DE DRAGOCIDIN 1 PRECURSOR; DRAGON FLAMEDUCT ANTIMICROBIAL PEPTIDE 1 OS DRAGONIS MYTHICUS (COMMON FLAMEBREATHING DRAGON/REPTILE/DRAGONID). DT 994 RN [1] RP SEQUENCE FROM N.A. RC TISSUE=FLAMEDUCT RA ARTHUR K., LANCELOT S, MERLIN W. GUENEVEVE Q. RL J. MYTH. BIOL. 209:1-6 (994). RN [2] RP STRUCTURE BY NMR RA CINDERELLA A., SLEEPING BEAUTY B., SNOW-WHITE C. RL J. STRUCT. MYTH. BIOCHEM. 13: 799-813 (997) CY S-S BRIDGED PEPTIDE (6 CYS) TY MULTIPLE S-S BRIDGED. FY DRAGOCIDINS. ST PDB Structure 1MYT. AY ANTIBACTERIAL: G+ (MIC= (MICROMOLAR) S.FLAMEUS:2, B. SCORCHIS:4) AY ANTIBACTERIAL: G- (MIC= (MICROMOLAR) P.THERMOPHYLUS:10) CC -!- FUNCTION: ANTIBACTERIAL PEPTIDE THAT PROTECTS THE FLAMEDUCT CC OF ADULT DRAGONS FROM THERMORESISTANT BACTERIAL STRAINS. CC -!- SIMILARITY: TO HEAT STABLE ANTIMICROBIAL PEPTIDES FROM OTHER CC DRAGON SPECIES. KW ANTIBIOTIC, SIGNAL. FT SIGNAL 1 6 FT CHAIN 7 47 ANTIMICROBIAL PEPTIDE MW COMPLETE SEQUENCE: 5279.5 (SH); MATURE PEPTIDE: 4560.5 (S-S). SQ 47 AA; DGCN_DRAMY mklkvlqaclnivlavmvdeakafrgnrksctrgcrfgvrcfvccvq*
NOTES:
The first part before the underscore relates to the peptide name while the
part after the underscore to the organism. Therefore DraGoCidiN from DRAgonis
MYthicus becomes DGCN_DRAMY, and CECropin A from DROsophila MElanogaster becomes
CECA_DROME.
For more common organisms, the common name e.g. BCT1_BOVIN, C18_RABIT,
FA39_HUMAN, PR39_PIG, DEF1_MOUSE is used.
Also indicated are the origin of the entry (STANDARD = Swiss-Prot entry,
LOCAL = Trieste entry, SUBMITTED = submitted entry, TRANSLATE = Converted from
EMBL/Genbank database entry), the type of sequence (PRT = protein) and the
length in AA.
ID is the entry
name. This is not necessarily the same as the Swiss-Prot ID.
AC is the accession
number. Normally the Swiss-Prot accession number is given here as a hyperlink to
this database so if you are
submitting a new entry leave it empty, unless the sequence is present in a
database other than Swiss-Prot (indicate which in parentheses)
DE is the
description. All commonly used names for the peptide/protein should be
present.
OS is the organism.
Where possible, its common name is given in parentheses, as well as some taxonomic information.
DT is the
date the sequence was first reported.
RN is the sequential
reference number
RP is a comment on
the type of information provided, e.g. on the origin of the sequence
reported in the reference numbered RN [n], or of the type of information given:
RC is the
tissue/strain from which the peptide/protein or respective mRNA/cDNA was
extracted (e.g. seed, trachea, bone marrow).
RA Authors or name
of person submitting an unpublished sequence.
RL Journal , or
SUBMITTED if not published.
CY is the category
- one of the following three:
if the sequence is that of a precursor it is
indicated by appending PRECURSOR OF
TY is the structure or
sequence type - one of the following:
FY is the family (if
any) to which the peptide belongs - eg:
ST is the a link to the PDB
structure entry
AY is the activity
- one of the following:
CC comments on
function, similarity to other peptides, post-translational modifications,
origin, measured molecular mass etc.
KW are keywords ,
generally taken directly from the Swiss-Prot entries.
FT contains sequence
features (e.g. the position of SIGNAL sequences; of the main CHAIN/PEPTIDE;
of DISULPHIDE bridges; of MODified RESidues, such as PYRROLIDONE CARBOXYLIC ACID
if present; of any CONFLICTing residues, of C-terminal AMIDATION, etc.)
MW gives the
molecular weight of the complete sequence, of pro-peptides and of the mature
sequence. Post translational modifications are indicated. For example (SH)
indicates cysteines are reduced, whereas (S-S) that disulphide bridges are taken
into account
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